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SUMMARY
EFFICACY

The Majority of Pediatric Patients respond well to ClaritineTM1

82%

of children treated with ClaritineTM (loratadine) had a good or excellent therapeutic response1



1. Lutsky BN, Kl.se P, Melon J, et al. A comparative study of the efficacy and safety of loratadine syrup and 1993;15(5):855-65
terfenadine suspension in the treatment of 3- to 6-year-old children with seasonal allergic rhinitis. Clin Ther.

ClaritineTM is effective across multiple allergic rhinitis symptoms in children1


Children receiving ClaritineTM had a lower TSS across multiple symptoms when compared with a placebo1

Adapted from Yang YH et al. 2001 trial involving 46 children (aged 3−12 years) with allergic rhinitis.2 Results from a 3-week, double-blind, placebo-controlled, randomised TSS=total symptom score; qd=once daily week (day 15-day 21) symptom scores from the diary cards between the two groups. The efficacy of loratadine syrup for these 4 symptoms was evaluated by comparing the last

1. Yang YH, Lin YT, Lu MY, et al. A double-blind, placebo-controlled, and randomized study of loratadine (ClaritineTM) syrup for the treatment of allergic rhinitis in children aged 3 to 12 years. Asian Pac J Allergy Immunol. 2001;19(3):171-55

ClaritineTM is effective across multiple allergic rhinitis symptoms in children1

Children receiving ClaritineTM (loratadine qd) had 3-week therapeutic period1 a significantly lower TSS vs placebo during the 3-week therapeutic period1.


 

Adapted from Yang YH et al. 2001
Results from a 3-week, double-blind, placebo-controlled, randomised trial involving 46 children (aged 3−12 years) with allergic rhinitis.2
TSS=total symptom score; qd=once daily.
The efficacy of loratadine syrup for these 4 symptoms was evaluated by comparing the last week (day 15-day 21) symptom scores from the diary cards between the two groups.

1. Yang YH, Lin YT, Lu MY, et al. A double-blind, placebo-controlled, and randomized study of loratadine (ClaritineTM) syrup for the treatment of allergic rhinitis in children aged 3 to 12 years. Asian Pac J Allergy Immunol. 2001;19(3):171-55

With one dose per day that lasts for 24hrs, ClaritineTM is the shield that allows children to treat their allergy monster all day and night.1,2
 

1. Mendoza de Morales T, S.nchez F. Clinical efficacy and safety of a combined Loratadine betamethasone oral solution in the treatment of severe pediatric perennial allergic rhinitis. World
2. Yang YH, Lin YT, Lu MY, et al. A double-blind, placebo-controlled, and randomized study of loratadine (ClaritineTM) syrup for the treatment of allergic rhinitis in children aged 3 to 12 years. Allergy Organ J. 2009;2(4):49-53 Asian Pac J Allergy Immunol. 2001;19(3):171-5

TOLERABILITY

ClaritineTM is well tolerated in the treatment of AR in patients as young as 2 years old.1
 



qd=once-daily
Adapted from Salmun LM et al. 2000.
Results from a 15-day randomised, double-blind placebo controlled study evaluating the safety of ClaritineTM(loratadine 5 mg qd) in 121 paediatric AR patients between 2 and 5 years of age.1


1. Salmun LM, Herron JM, Banfield C, et al. The pharmacokinetics, electrocardiographic effects, and tolerability of loratadine syrup in children aged 2 to 5 years. Clin Ther. 2000;22(5):613-21.

Short-term administration of ClaritineTM (loratadine) does not impair children’s performance in school.1





Adapted from Bender et al. 2001. Results from a parallel-group, double-blind, placebo Controlled study on 63 children between 8 and 10 years of age with allergic rhinitis. short-term administration of diphenhydramine or loratadine. J Pediatr. 2001;138(5):656-60

1. Bender BG, McCormick DR, Milgrom H. Children’s school performance is not impaired by

DOSING

Children aged 2 to 12 years are dosed according to their weight:
 

Body weight above 30 kg:
Take once daily 10 ml (measuring cup filled to 10 ml line).


Body weight 30 kg or less:
Give once daily 5 ml (measuring cup filled to 5 ml line).


 

1. Claritine Abbreviated Prescribing Information

SUMMARY
ClaritineTM offers 24-hour relief from allergic rhinitis symptoms triggered by indoor and outdoor allergens.1,2

(ClaritineTM) syrup for the treatment of allergic rhinitis in placebo-controlled, and randomized study of loratadine 1-Yang YH, Lin YT, Lu MY, et al. A double-blind, rhinitis patients are different: new factors that may play a role. children aged 3 to 12 years. Asian Pac J Allergy Immunol. 2001;19(3):171-5 2- M.sges R, Klimek L. Today’s allergic Allergy. 2007 Sep;62(9):969-75.
ClaritineTM is administered once a day.1,2

(ClaritineTM) syrup for the treatment of allergic rhinitis in placebo-controlled, and randomized study of loratadine

1. Yang YH, Lin YT, Lu MY, et al. A double-blind, non-sedating antihistamine. Review of its effects on cognition, children aged 3 to 12 years. Asian Pac J Allergy Immunol. psychomotor performance, mood and sedation. Clin Exp 2001;19(3):171-5 2. Kay GG, Harris AG. Loratadine: an Allergy. 1999;29 Suppl 3:147-50

As ClaritineTM is a non-drowsy antihistamine,
it has no significant impact on a child’s learning activities.
1,2


1. Mir E, Panjabi C, Shah A. Impact of allergic rhinitis in school 2. Bender BG, McCormick DR, Milgrom H. Children’s school going children. Asia Pac Allergy. 2012;2(2):93–100 administration of diphenhydramine or loratadine. J Pediatr. performance is not impaired by short-term 2001;138(5):656-60

ClaritineTM has rephrase to favorable safety profile and is well tolerated by children.1,2

Sep;62(9):969-75 2. Salmun LM, Herron JM, Banfield C, et al. 1. M.sges R, Klimek L. Today’s allergic rhinitis patients are tolerability of loratadine syrup in children aged 2 to 5 years. The pharmacokinetics, electrocardiographic effects, and different: new factors that may play a role. Allergy. 2007 Clin Ther. 2000;22(5):613-21
In liquid and tablets formulations, ClaritineTM is easy to administer and facilitates adherence.1,2

1. Venables R, Batchelor H, Hodson J et al. Determination of 2015;480(1-2):55-62 2. Davies EH, Tuleu C. Medicines for children: an acceptability in a domiciliary paediatric population. Int J Pharm. formulation factors that affect oral medicines matter of taste. J Pediatr. 2008;153(5):599-604, 604.e1-2

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