Inflammation Phase 1
  • • Chlorhexidine and Dexpanthenol work synergistically to protect against infection.2
  • • It is well tolerated by patients.3
Proliferation Phase 2
  • • Wound healing support:
    Dexpanthenol is proven to enhance wound healing.4,5
Bepanthen® Plus Wound Healing Cream

Bepanthen® Anti-Scar Gel with Massage Device6

Remodeling Phase 3
Bepanthen® Anti-Scar Gel
Silicon based
  • • Provides occlusion and reduces TEWL.7
  • • Improves appearance of hypertrophic scars.8
Proven moisturizer
  • • Dexpanthenol improves skin hydration.9
  • • Dexpanthenol increases mobility of lipids in stratum corneum.10
Massage of older scars
  • • The massage ball helps break down collagen fibres in scars over 1 month.8

References:
1.Bepanthen Plus Cream Product Information Leaflet. 2.Kramer A et al. Antimicrobial efficacy of the combination of chlorhexidine digluconate and dexpanthenol. GMS Hygiene Infect Control 2016;11:1–6. 3.About Chlorhexidine: Mechanism of Action. Available at https://www.chlorhexidinefacts.com/mechanism-of-action.html , last accessed on 7th of September 2021. 4.Marquardt Y et al. Characterization of a novel standardized human three-dimensional skin wound healing model using non-sequential fractional ultrapulsed CO2 laser treatments. Lasers Surg Med 2015;47:257–65. 5.Wiederholt T et al. Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol 2009;18:969–78. 6.Bepanthen AntiScar Gel Product Information Leaflet. 7.Nast A et al. Scar management: using silicone-based products in primary health care. Wounds Int 2016;7(4):23–7. 8.Hans Stettler et al. Clinical innovation: Treatment with an anti-scar gel and massage ball improves physical parameters of hypertrophic scars. Wounds International 2016 | Vol 7 Issue 3 | ©Wounds International 2016 | www.woundsinternational.com. 9.Gehring W and Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittel-Forschung Drug Research 2000;7:659–63. 10.Björklund S et al. The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier. Colloid Interface Sci. 2016 Oct 1;479:207-220.