CLARITINE™ (LORATADINE)
MAY PROVIDE MORE
EFFECTIVE EARLY SYMPTOM
RELIEF THAN FEXOFENADINE.1
Reduction in average daily reflective
symptom score, day 21
Claritine™ vs. Fexofenadine SYMPTOMS RELIEF IN SEASONAL ALLERGIC RHINITIS PATIENTS
The daily differences in motivation#
between Claritine™ and cetirizine
groups were consistent over the 7
days of the study.1
The use of Claritine™ in patients with AR is associated with GREATER MOTIVATION during the workday than the use of cetirizine. Statistically significant difference in motivation between the Claritine™ and cetirizine groups were noted at 10:00 AM (p = 0.014), noon (p = 0.001), and 3:00 PM (p< 0.001), indicating that patients taking ClaritineTM were relatively more motivated.1
#Motivation was assessed using a visual analog scale ranging from 1 = fully motivated to 10 = not motivated at all. Assessments made at 8:OO AM, 10:00 AM, noon, and 3:00 PM for 7 days were pooled, and a mean (± SEM) score was calculated for each day.1 qd: Once daily; AR: Allergic rhinitis.1. Salmun LM, Gates D, Scharf M, Greiding L, Ramon F, Heitho K. Loratadine versus cetirizine: assessment of somnolence and motivation during the workday. Clin Ther. 2000;22(5):57382.
The daily profile of motivation# to perform activities of claritine™ and Cetrizine groups1
The use of Claritine™ showed GREATER IMPROVEMENT than placebo in daytime nasal symptoms score and night-time symptom score.1
1. Philip G, Malmstrom K, Hampel FC, et al. Montelukast for treating seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled trial performed in the spring. Clin Exp Allergy. 2002;32(7):10208.Day and Night Symptom Control Significantly greater improvement in daytime and night-time symptoms.
The Whole Day Effect
The effect of Claritine™ will last a whole day and should help allergic rhinitis patients to continue their normal daily activities and sleep.1
1. Claritine tablets Package Leaflet.
After single recommended doses, cetirizine is sedative and impairing whereas Claritine™ is not.1
Cetirizine 10 mg possesses acute sedative activity. It significantly impaired driving performance (p <0.02) and caused marked feelings of drowsiness during driving.1
1. Ramaekers, J. G., Uiterwijk, M. M., & O'Hanlon, J. F. (1992). Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving. European journal of clinical pharmacology, 42(4), 363–369. https://doi.org/10.1007/BF00280119Claritine™ (loratadine 10 mg) had no significant effect on any of the measured variables.1
The differences in somnolence# between Claritine™ and cetirizine groups were consistent each day and did not diminish over the 7 days of the study.1
#Somnolence was assessed using a visual analog scale ranging from 1 = wide awake to 10 = extremely somnolent. Assessments made at 8:00 AM, 10:00 AM, noon, and 3:00 PM for 7 days were pooled, and a mean (± SEM) score was calculated for each day.1 qd: Once daily; AR: Allergic rhinitis.1. Salmun LM, Gates D, Scharf M, Greiding L, Ramon F, Heitho K. Loratadine versus cetirizine: assessment of somnolence and motivation during the workday. Clin Ther. 2000;22(5):57382.
The daily somnolence profile# of the Claritine™ and Cetrizine groups1
Once
Daily
One
Tablet
Recommended for adults
and children above 6 years old
1. Claritine™ Tablet Package Leaflet.
- Claritine™ may provide more effective early symptom relief than fexofenadine.1
- Claritine™ is associated with greater motivation during the workday than cetirizine.2
- Unlike cetirizine, Claritine™ had no significant effect on driving performance.3
- The effect of Claritine™ lasts a whole day.4
- Claritine™ Tablet Package Leaflet.
- https://www.accessdata.fda.gov/drugsatfda_docs/label/
2002/19835s15,%2020346s8lbl.pdf. Last accessed at: 12/9/2022. - https://www.accessdata.fda.gov/drugsatfda_docs/label/
2008/020872s018,021963s002lbl.pdf. Last accessed at: 12/9/2022. - https://www.accessdata.fda.gov/drugsatfda_docs/
label/2000/20641s7lbl.pdf. Last accessed at: 12/9/2022.