American College of Cardiology, American Heart Association,
Society for Cardiovascular Angiography and Interventions.
Aspirin Loading dose of 162-325 mg orally & Maintenance dose of 75-100 mg orally daily.
In selected patients undergoing PCI, shorter duration DAPT (1–3months) is reasonable, with subsequent transition to P2Y12 inhibitor monotherapy to reduce the risk of bleeding events (class 2a, level A).
Clinicians should weigh the risks of bleeding and recurrent ischemia when determining the choice of DAPT.1
In patients undergoing CABG who are already taking daily aspirin preoperatively, it is recommended that they continue taking aspirin until the time of surgery to reduce ischemic events
(class I, level B-R).1
In patients referred for urgent CABG, clopidogrel and ticagrelor should be discontinued for at least 24 hours before surgery to reduce major bleeding complications
(class I, level B-NR)1
In patients undergoing elective CABG who are not already taking aspirin, the initiation of aspirin (100–300 mg daily) in the immediate preoperative period (<24 hours before surgery) is not recommended
(class 3: no benefit, level B-R).1
In patients undergoing CABG, aspirin (100–325 mg daily) should be initiated within 6 hours postoperatively and then continued indefinitely
(class I, level A).1
In selected patients undergoing CABG, DAPT with aspirin and ticagrelor or clopidogrel for 1 year may be reasonable
(class IIb, level B-R).1
ACC: American College of Cardiology; AHA: American Heart Association; SCAI: Society for Cardiovascular Angiography and Interventions; CABG: coronary artery bypass graft; DAPT: dual antiplatelet therapy.P2Y12: platelet adenosine diphosphate.
Reference